How does sildenafil citrate work

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    Allergy
  • Anthelmintics
  • Anti Bacterial
  • Anti Convulsants
  • Anti Depressants
  • Anti Fungal
  • Anti Viral
  • Antibiotics
  • Arthritis
  • Asthma
  • Bladder And Gout
  • Blood Pressure
  • Cancer
  • Cardiovascular
  • Cholesterol
  • Diabetes
  • Diuretics
  • Erectile Dysfunction
  • Gastrointestinal
  • Hair Loss
  • Heartburn
  • Inflammatory
  • Lung Diseases
  • Men's Health
  • Mental Disorders
  • Migraines
  • Muscle Relaxers
  • Neurologic Diseases
  • Osteoporosis
  • Other
  • Pain Medicine
  • Parkinson And Alzheimer
  • Respiratory
  • Skin Care
  • Stop Smoking
  • Surgery
  • Thyroid
  • Weight Loss
  • Women's Health
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    Mens issues

    Erectile dysfunction (ED, "male impotence ") is a sexual dysfunction characterized by the inability to develop or maintain an erection of the penis sufficient for satisfactory sexual performance.

    An erection occurs as a hydraulic effect due to blood entering and being retained in sponge-like bodies within the penis. The process is most often initiated as a result of sexual arousal, when signals are transmitted from the brain to nerves in the penis. Erectile dysfunction is indicated when an erection is difficult to produce. There are various circulatory causes, including alteration of the voltage-gated potassium channel as in the case of arsenic poisoning from drinking water. The most important organic causes are cardiovascular disease and diabetes, neurological problems (for example, trauma from prostatectomy surgery), hormonal insufficiencies (hypogonadism) and drug side effects. It is important to realize that erectile dysfunction can signal underlying risk for cardiovascular disease.[citation needed]

    Psychological impotence is where erection or penetration fails due to thoughts or feelings (psychological reasons) rather than physical impossibility; this is somewhat less frequent but often can be helped. Notably in psychological impotence, there is a strong response to placebo treatment. Erection, tied closely as it is about ideas of physical well being, can have severe psychological consequences. There is a strong culture of silence and inability to discuss the matter.[citation needed] In reality, it has been estimated that around 1 in 10 men will experience recurring impotence problems at some point in their lives.

    Besides treating the underlying causes such as potassium deficiency or arsenic contamination of drinking water, the first line treatment of erectile dysfunction consists of a trial of PDE5 inhibitor drugs (the first of which was sildenafil or Viagra). In some cases, treatment can involve prostaglandin tablets in the urethra, intracavernous injections with a fine needle into the penis that cause swelling, a penile prosthesis, a penis pump or vascular reconstructive surgery.

    The Latin term impotentia coeundi describes simple inability to insert the penis into the vagina. It is now mostly replaced by more precise terms.[vague] The study of erectile dysfunction within medicine is covered by andrology, a sub-field within urology.

    How does sildenafil citrate work

    Sildenafil citrate, sold as Viagra, Revatio and under various other trade names, is a drug used to treat erectile dysfunction and pulmonary arterial hypertension (PAH). It was developed and is being marketed by the pharmaceutical company Pfizer. It acts by inhibiting cGMP specific phosphodiesterase type 5, an enzyme that regulates blood flow in the penis. Since becoming available in 1998, sildenafil has been the prime treatment for erectile dysfunction; its primary competitors on the market are tadalafil (Cialis) and vardenafil (Levitra).

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